The Science of Fibromyalgia


Fibromyalgia research has shown it to be a multi-faceted condition with brain dysfunction at its core.

Are you ready to get back to living? Call (717) 697-0589 today and request your new patient paperwork.

Our approach to beating pain is grounded in science. If a therapy or treatment has not been scientifically proven to be applicable or effective, we do not use it. To put it another way, this is evidence-based care. We would encourage you to ask your current provider to share with you the evidence or research behind what they do.

Here’s how we beat fibromyalgia:

We test for imbalances in your immune system:

  • Gur A, Oktayogly P. Status of immune mediators in fibromyalgia. Curr Pain Headache Report. 2008;12(13)175-181. read me
  • Gur A, et al. Cytokines and depression in cases with fibromyalgia. J Rheumatology. 2002;29(2):358-361. read me
  • Bazzichi L, et al. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatology. 2007;25(2):225-230. read me
  • Paiva ES, et al. Fibromyalgia: an update and immunological aspects. Curr Pain Headache Rep. 2008;12(5):321-326. read me
  • Wallace DJ, et al. Cytokines play an aietiopathogenic role in fibromyalgia: a hypothesis and pilot study. Rheumatology. 2001;40(7):743-749. read me
  • Di Franco M, et al. Neuroendocrine Immunology of fibromyalgia. Ann NY Acad Sci. 2010;1193:84-90. read me

We test for imbalances in your gastrointestinal system:

  • Goebel A, et al. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Rheumatology. 2008;47(8):1223-1227. read me
  • Lin HC. Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA.2004;292(7):852-858. read me
  • Posserud I, et al. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut. 2007;56(6):802-808. read me
  • Chang L, et al. Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia. Am J Gastroenterol. 2003;98(6):1354-1361. read me

We test for imbalnces in your endocrine system:

  • Pillemer SR, et al. The neuroscience and endocrinology of fibromyalgia. Arthritis Rheum. 1997;40(11):1928-1939. read me
  • Adler GK, et al. Hypothalamic-pituitary-adrenal and autonomic nervous system functioning in fibromyalgia. Rheum Dis Clin North Am. 2005;31(1):187-202. read me
  • Lekander M, et al. Neuroimmune relations in patients with fibromyalgia: a positron emmision tomography study. Neurosci Lett. 2000;282(3):193-196. read me

We have a thorough understanding of the neurology of chronic pain:

  • Russell IJ. Neurochemical pathogenesis of fibromyalgia. Z Rheumatol. 1998;57(2):63-66. read me
  • Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain. 1997;70(1):41-51. read me
  • Staud R, Smitherman ML. Peripheral and central sensitization in fibromyalgia: pathogenic role. Curr Pain Headache Report. 2002;6(4):259-266. read me
  • Staud R. Evidence of involvement of central neural mechanisms in generating fibromyalgia pain. Curr Rheumatology Rep. 2002;4(4):299-305. read me
  • Staud R,et al. Abnormal sensitization and temporal summation of second pain (wind up) in patients with fibromyalgia syndrome. Pain. 2001;91(1-2):165-175. read me
  • Cook DB, et al. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol. 2004;31(2):364-378. read me
  • Desmeules JA, et al. Neurophysiologic evidence for central sensitization in patients with fibromyalgia. Arthritis Rheum. 2003;48(5):1420-1429. read me
  • Lautenbacher S, Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. Clin J Pain. 1997;13(3):189-196. read me
  • Petzke F, Clauw DJ. Sympathetic nervous system function in fibromyalgia. Curr Rheumatol Rep. 200;2(2):116-123. read me
  • Bennett Rm. Emerging concepts in the neurobiology of chronic pain: evidence of abnormal sensory processing in fibromyalgia. Mayo Clin Proc. 1999;74(4):385-395. read me
  • Meeus M, Nijs J. Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol. 2007;26(4):465-473. read me
  • Watson NF. Neurologic signs and symptoms if fibromyalgia. Arthritis Rheum. 2009;60(9):2839-2844. read me
  • Russell IJ, Larson AA. Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis. Rheum Dis Clin North Am. 2009;35(2):421-435. read me
  • Arias M. Is fibromyalgia a neurological disease? Neurologia. 2008;23(9):593-601. read me
  • Mountz JM, et al. Abnormal functional activity of the central nervous system in fibromyalgia syndrome. Am J Med Sci. 1998;315(6):385-396. read me
  • Bradley LA, et al. Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia. Curr Rheumatol Rep. 2000;2(2):141-148. read me
  • Staud R, et al. Brain activity associated with slow temporal evoked pain in fibromyalgia patients and healthy conrtols. Eur J Pain. 2008;12(8):1078-1089. read me
  • Burgmer M, et al. Altered brain activity during pain procesing in fibromyalgia. Neuroimage. 2009;44(2):502-508. read me

We use enhanced oxygen therapy for our patients:

  • Alvarez LB, et al. Fibromyalgia syndrome: overnight falls in arterial blood oxygen saturation. Am J Med. 1996;101(1):54-60. read me
  • King S, et al. Tumor necrosis factor, Interleukin 1B and tissue oxygen levels in myofascial pain and fibromyalgia syndromes. J Muskuloskel Pain. 1997;5(3):53-66. read me
  • Katz DL, et al. The pain of fibromyalgia is caused by muscle hypoperfusion induced by regional vasomotor dysregulation. Med Hypotheses. 2007;69(3):517-525. read me
  • Meiworm L, et al. Patients with fibromyalgia benefir from aerobic endurance exercise. Clin Rheumatol. 2000;19(4):253-257. read me

We use high potency antioxidants in our chronic pain treatment:

  • Bagis S, et al. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int. 2005;25(3):188-190. read me
  • Ozgocmen S, et al. Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns. Rheumatol Int. 2006;26(7):598-603. read me
  • Iqbal R, et al. Pathophysiology and antioxidant status of patients with fibromyalgia. Rheumatol Int. 2011;31(2):149-152. read me

We use an evidence-based approach to the clinical management of fibromyalgia:

  • Simms RW. Fibromyalgia is not a muscle disorder. Am J Med Sci. 1998;315(6):346-350. read me
  • Henriksson KG. the fibromyalgia syndrome: translating science into clinical practice. J Muskuloskel Pain. 2009;17(2):189-194. read me
  • Goldenberg DL, et al. Management of fibromyalgia syndrome. JAMA. 2004;292(19):2388-2395. read me
  • Cymet TC. A practical approach to fibromyalgia. J Natl Med Assoc. 2003;95(4):278-285. read me
  • Lind BK, et al. Use of complimentary and alternative medicine providers by fibromyalgia patients under insurance coverage. Arthritis Rheum. 2007;57(1)71-76. read me
  • Fiechtner JJ, Brodeur RR. Manual and manipulation techniques for rheumatic disease. Med Clin North Am. 2002;86(1):91-103. read me
  • Bennett R. Fibromyalgia, chronic fatigue syndrome and myofascial pain. Curr Opin Rheumatol. 1998. 10(2):95-103. read me
  • Buskila D. Fibromyalgia, chronic fatigue syndrome and myofascial pain syndrome. Curr Opin Rheumatol. 2001;13(2):117-127. read me
  • Alentorn-Geli E, et al. Six weeks of whole-body vibration exercise improves pain and fatigue in women with fibromyalgia. J Altern Compliment Med. 2008;14(8):975-981. read me
  • Hollins M, ey al. Vibratory antinociception: effects of vibration amplitude and frequency. J Pain. 2003;4(7):381-391. read me
  • Kosek E. Advances in fibromyalgia treatment: understanding endogenous pain modulation. Int J Clin Rheumatol. 2009;4(5):493-497. read me

With testing and treatment grounded in research and science, your fibromyalgia could be a thing of the past.

To read about our Cutting-Edge Treatment for fibromyalgia, click here.

You deserve better! Don’t let another year go by suffering with fibromyalgia.